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Overall, our results provide new evidence that SMGCs may facilitate symbiosis with phylogenetically diverse hosts, highlighting the importance of microbial symbioses to drive fungal metabolic diversity.įranco, M.E., Wisecaver, J.H., Arnold, A.E., Ju, Y.-M., Slot, J.C., Ahrendt, S., Moore, L.P., Eastman, K.E., Scott, K., Konkel, Z., Mondo, S.J., Kuo, A., Hayes, R.D., Haridas, S., Andreopoulos, B., Riley, R., LaButti, K., Pangilinan, J., Lipzen, A., Amirebrahimi, M., Yan, J., Adam, C., Keymanesh, K., Ng, V., Louie, K., Northen, T., Drula, E., Henrissat, B., Hsieh, H.-M., Youens-Clark, K., Lutzoni, F., Miadlikowska, J., Eastwood, D.C., Hamelin, R.C., Grigoriev, I.V. Our results suggest that as host and substrate generalists, Xylariaceae endophytes experience greater selection to diversify SMGCs compared to more ecologically specialized Hypoxylaceae species.Enhanced metabolic diversity of endophytes is associated with a greater diversity of hosts and increased capacity for lignocellulose decomposition. All genomes contain hyperabundant SMGCs however, Xylariaceae have increased numbers of gene duplications, horizontal gene transfers (HGTs), and SMGCs.Re-evaluation requests should be submitted to the Office of the Registrar in person on the 5th floor of the Student Success Center or via the postal or email address ( ). We paired genomic data with extensive metadata on endophyte hosts and substrates, enabling us to examine genomic factors related to the breadth of symbiotic interactions and ecological roles. Effective March 2020, current students who need to appeal 000 transfer credit should use the transfer credit re-evaluation form. and Hypoxylaceae), including 88 newly sequenced genomes of endophytes and closely related saprotrophs and pathogens. Here, we examined secondary metabolite gene clusters (SMGCs) across 96 Xylariales genomes in two clades (Xylariaceae s.l.He is also the CARS representative on General Education council. Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning all lineages of land plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phylogenetically diverse hosts. Brian currently works as the liaison to Cluster 1 of the General Education program, working on assessment activities for human communication, written communication, information literacy, and critical thinking.